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| | | | | | Volume-I,
Issue-II, April-June 2012 | | | Research
Scapes
(An International Multi Disciplinary Journal) |
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| Comparative Study
on Commercially Available Samples Containing Paracetamol as API CLICK HERE TO
ABSTRACT GAntipyretics
& Analgesics are widely used for the fever and different types of body aches.
Paracetamol is one, which has antipyretic & analgesic properties. For the
present study five brands of easily available samples from the market were compared
for their physical and chemical properties and comparative study was made using
various apparatus and instruments. To check the quality of paracetamol in different
brand the sample were subjected to API test. A comparison was made between the
claimed value of the different brand and the observed value. The comparative study
results of various antipyretic analgesic samples are discussed in the paper.
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| Evaluation Offer Menation
Condition for Production of Endopolygalacturonase by fungal strain in Solid State
Fermenation CLICK HERE TO ABSTRACT The
production of enzymes by bioprocesses is a good alternative to add value to agro
industry residues. Endo PG’s enzyme production was attempted using Aspergillus
niger (ATUV08), from the mixture of wheat straw and mosambi peel extract (9:1)
under Solid state fermentation. Among the various carbon source and heavy metals
were tested, highest yield of pectinase production was observed for starch 39.0
IU ml-1 mg-1 as the carbon source in solid state fermentation. The Endo PG’s
production (37.4 IU ml-1 mg-1) was found to be higher in the pH 5.0. A maximum
endo PG’s production of 37.8 IU ml-1 mg-1 was obtained in the presence of
Zinc sulphate followed by ferric chloride 37.4 IU ml-1 mg-1 at 1 M concentration
in solid state medium. The present study showed that the fungal strain Aspergillus
niger has high potential for industrial productions of Endo PG’s. |
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| Modulation of Carcinogeni
City by Ocimum sanctum Extract in Swiss Albino and C57BL Mice CLICK HERE TO ABSTRACT
The
anticarcinogenic activity of Ocimum extract was evaluated using two stage protocol
in skin papiloma model in swiss albino mice and melanomas model in C57Bl tumor
bearing mice. Significant prevention in number of papilomas was observed in DMBA+
Ocimum extract +Croton oil group as compared to DMBA+Croton oil. The first appearance
of papilloma was also delayed in DMBA Ocimum extract + Croton oil group (52 days)
as compared to DMBA+ Croton oil group (29 days).The cumulative numbers of papillomas
was also reduced in DMBA+ Ocimum extract + Croton oil group (7) as compared to
DMBA+ Croton oil group (40). In another experiment the anticarcinogenicity of
Ocimum extract was also studied using melanoma tumour model in the C57 B1 mice.
The mice which received extract of Ocimum at the dose of 500 mg/Kg body weight
for 30 days showed increase in life span of animals and tumour size was significantly
reduced in Ocimum extract treated mice as compared to control. The tumor volume
was significantly reduced to 69% and 73% in Ocimum extract treated mice as compared
to untreated control animals. These results suggest the anticarcinogenic activity
of Ocimum extract and it may be an alternative medicine for chemotherapy of cancer
treatment. | | | | |
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