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| Pharmaceutical
Science Issues | | | |
| Volume-I,
Issue-I, January-March 2012 | | | Research
Scapes
(An International Multi Disciplinary Journal) |
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| Development and Validation
of Spectrophotometric Method for Simultaneous Estimation of Lornoxicam and Paracetamol
in Tablet Dosage Form by Dual Wavelength Method (Shailendra Bindaiya, Santosh
Kushwaha, Ameeta Argal) CLICK HERE TO ABSTRACT
A
precise, accurate, sensitive spectrophotometric method has been developed and
validated for the simultaneous estimation of Lornoxicam and Paracetamol in tablet
formulation. This method was based on UV-spectrophotometric determination of two
drugs, using dual wavelength method. It involves measurement of absorbance difference
at 286nm and 230.5nm were consider for estimation of Lornoxicam, at 257nm and
282nm were consider for estimation of Paracetamol. in 0.1 N NaOH. The linearity
was observed in the concentration range of 8-40 µg/ml & 10-50 µg/ml
for Lornoxicam and Paracetamol respectively. The accuracy and precision of the
method was determined and validated stastically. The method showed good reproducibility
and recovery with % RSD less than 2. The method was validated according to ICH
guidelines. | |
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